Action and therapeutic potential of oxyntomodulin

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Action and therapeutic potential of oxyntomodulin☆

Oxyntomodulin (OXM) is a peptide hormone released from the gut in post-prandial state that activates both the glucagon-like peptide-1 receptor (GLP1R) and the glucagon receptor (GCGR) resulting in superior body weight lowering to selective GLP1R agonists. OXM reduces food intake and increases energy expenditure in humans. While activation of the GCGR increases glucose production posing a hyperg...

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ژورنال

عنوان ژورنال: Molecular Metabolism

سال: 2014

ISSN: 2212-8778

DOI: 10.1016/j.molmet.2013.12.001